Asymmetric Hydrogenation of Alkenyl, Cyclopropyl, and Aryl Ketones. RuCl2(xylbinap)(1,2-diamine) as a Precatalyst Exhibiting a Wide Scope was written by Ohkuma, Takeshi;Koizumi, Masatoshi;Doucet, Henri;Pham, Trang;Kozawa, Masami;Murata, Kunihiko;Katayama, Eiji;Yokozawa, Tohru;Ikariya, Takao;Noyori, Ryoji. And the article was included in Journal of the American Chemical Society in 1998.Recommanded Product: 171032-87-4 This article mentions the following:
Binaphthylbisphosphinodiamineruthenium complexes I [R = 3,5-Me2C6H3; R1 = 4-MeOC6H4, Ph; R2 = H, 4-MeOC6H4; R3 = Me2CH, Ph or R1R3 = (CH2)4] are prepared in either the all-S or all-R configuration as enantioselective and regioselective catalysts for the reduction of α,β-unsaturated ketones, cyclopropyl ketones, and arylalkyl ketones to secondary alcs. α,β-Unsaturated ketones were reduced with H2 in Me2CHOH in the presence of I and either K2CO3 or KOCMe3 in 98-100% yield and 86-100% ee and without reduction of the conjugated double bond. Arylalkyl ketones were reduced under similar conditions in 97-100% yield and in 94-100% ee. E.g., 4-MeOC6H4COMe was reduced with the catalyst (S,S)-I in Me2CHOH and in the presence of KOCMe3 (R = 3,5-Me2C6H3; R1 = R2 = 4-MeOC6H4; R3 = CHMe2) to (R)-4-MeOC6H4CH(OH)Me in 100% yield and 100% ee. The addition of chiral diamines to Ru-BINAP catalysts gives catalysts with higher stereoselectivity and wide scope in asym. ketone reductions In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 171032-87-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts