Conversion of S-2-amino-1-butanol-
In this work, a green route for the preparation of S-2-amino-1-butanol in process of post-treatment for direct enantioseparation for antituberculosis drug ethambutol hydrochloride has been explored. Therein, OH– produced from bipolar membrane electrodialysis (BMED) technol. was used to in situ converse diastereomeric salt S-2-amino-1-butanol-L-tartrate to S-2-amino-1-butanol, rather than directly adding the chem. reagent of NaOH or Na2CO3 in a traditional way. To realize the process, lab-scale BMEDs with two membrane stack configurations were fabricated, followed by investigating the effect of ion exchange membrane types, initial feed concentrations and voltages etc. As a result, under an optimized condition, the concentration of as-obtained S-2-amino-1-butanol (the final purity of the product: ca. 98.2%) can achieve to 1.04 mol·L-1, and the conversion rate is 92.28%. The cost is estimated at approx. $ 2.22 kg-1. Accordingly, the current efficiency and energy consumption are 54.05% and 1.88 kWh·kg-1, resp. The investigation has verify the feasibility of BMED for the conversion of S-2-amino-1-butanol-L-tartrate to S-2-aminobutanol and also demonstrates the potential application in the field of chiral compound separation In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3HPLC of Formula: 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts