Ospemifene for the treatment of vulvar and vaginal atrophy: A meta-analysis of randomized trials. Part I: Evaluation of efficacy was written by Di Donato, Violante;schiavi, Michele Carlo;iacobelli, Valentina;D’oria, Ottavia;Kontopantelis, Evangelos;Simoncini, Tommaso;Muzii, Ludovico;Benedetti Panici, Pierluigi. And the article was included in Maturitas in 2019.Recommanded Product: 128607-22-7 This article mentions the following:
Objective: To evaluate the efficacy of ospemifene in treating dyspareunia associated with postmenopausal vulvo-vaginal atrophy (VVA). Methods: A structured search was carried out in PubMed-Medlin, Embase, Cochrane Controlled Trials Register databases through to 31 July 2018. The search included the following terms: “Ospemifene”, “vulvovaginal atrophy”, “dyspareunia”, “SERM” and “randomized controlled trial” (RCTs). Four outcomes were selected: vaginal pH; proportions of parabasal and superficial vaginal cells; and perception of the most bothersome symptom (vaginal dryness or dyspareunia). A random-effects model was used in the meta-anal. Study quality and bias risk were assessed with the Cochrane tool. Results: Six RCTs comparing the efficacy of ospemifene against placebo after 12 and 52 wk of treatment were included in the meta-anal. At 12 wk, changes in vaginal Ph (SMD: -0.96, 95% CI:-1.12 to -0.81; p < 0.0001), parabasal cells (SMD: -36.84 95% CI -46.95 to -26.72; p < 0.0001), superficial cells (SMD: 8.23, 95% CI 3.73-12.74, p < 0.0003), and dyspareunia (SMD= – 2.70, 95% CI – 2.88 to -2.52, p < 0.0001) indicated that ospemifene was more effective than placebo. Conclusion: The present meta-anal. suggests that ospemifene 60 mg is associated with significant improvement in the morphol. and physiol. features of the vaginal mucosa that correlate with the symptoms associated with postmenopausal VVA. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Recommanded Product: 128607-22-7).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 128607-22-7
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