Synthesis, and characterization folate-conjugated photocleavable poly(4-substituted-ε-caprolactone) polymers for drug delivery was written by Fang, Jia-You;Lin, Yin-Ku;Wang, Shiu-Wei;Lee, Ren-Shen. And the article was included in International Journal of Polymeric Materials and Polymeric Biomaterials in 2020.Recommanded Product: 60463-12-9 This article mentions the following:
Photo-cleavable polymers containing 5-hydroxy-2-nitrobenzyl alc. (ONB) junction point between the target mol. of folic acid (FA) and the hydrophobic poly(4-substituted-ε-caprolactone) (PXCLn) chain were synthesized. FA -terminated ONB-PXCLn polymers formed micelles with critical micelle concentration (CMC) 1.2 – 64.3 mg L-1. Fluorescence emission spectroscopy indicated the release of Nile red encapsulated FA-ONB-PXCLn micelles in response to irradiation Light-triggered bursts released were observed for drug-loaded FA-ONB-PXCLn micelles. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 300 μg mL-1. Flow cytometry revealed that the uptake of folate-targeted doxorubicin (DOX) -encapsulated micelles by HeLa cells was faster than that of free DOX. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 60463-12-9).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 60463-12-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts