Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon was written by Caiger, Lewis;Sinton, Conar;Constantin, Timothee;Douglas, James J.;Sheikh, Nadeem S.;Julia, Fabio;Leonori, Daniele. And the article was included in Chemical Science in 2021.Recommanded Product: 142253-56-3 This article mentions the following:
Here, a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive was reported. Halogen-atom transfer (XAT) from α-aminoalkyl radicals was leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde was rendered irreversible by trapping the transient O-radical with PPh3. This event delivered a phosphoranyl radical that re-generates the alkyl radical and provided the hydroxymethylated product. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Recommanded Product: 142253-56-3).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 142253-56-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts