Knowledge of genito-urinary syndrome of menopause among Italian gynecologists: the DIADEM survey was written by Alvisi, Stefania;Baldassarre, Maurizio;Gava, Giulia;Mancini, Ilaria;Cagnacci, Angelo;Seracchioli, Renato;Meriggiola, Maria Cristina. And the article was included in Maturitas in 2021.Application of 128607-22-7 This article mentions the following:
The objective of this study was to present an updated picture of the knowledge and attitudes of Italian gynecologists with regard to the genitourinary syndrome of menopause (GSM). An anonymous survey was sent via electronic mail to 3892 gynecologists. Three hundred and seventy-four out of 3892 invited Italian gynecologists replied to the survey (response rate 9.7%). Most (84%) had a good knowledge of GSM and 74% reported that they investigated it during clinic visits, but most of them underestimated its prevalence. The most frequently prescribed treatment was topical hormonal therapy (60%), followed by vaginal moisturizers and lubricants (16%), ospemifene (12%) and systemic hormone therapy (12%). According to the clin. experience of respondents, the most effective therapy is local hormonal therapy (36%), followed by ospemifene (30%). According to respondents, less than 50% of patients continue therapy after 12 mo, due to the discomfort in vaginal application, the cost of oral therapies and the fear of possible side-effects. With the limitation of the low response rate, this study suggests that although Italian gynecologists who answered the survey had some knowledge of GSM, they underestimated its prevalence, did not know its most bothersome symptoms and had inadequate knowledge of the efficacy of treatments, patient compliance and satisfaction. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application of 128607-22-7).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 128607-22-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts