Zhou, Jing’s team published research in Xin Zhongyi in 53 | CAS: 23828-92-4

Xin Zhongyi published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C11H10ClNO, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Zhou, Jing published the artcileClinical comparative study between Xiao′er feike granules and ambroxol hydrochloride syrup for chronic cough in children, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Xin Zhongyi (2021), 53(5), 120-123, database is CAplus.

Objective: To compare and analyze the clin. application value of Xiao′er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods: A total of 200 children with chronic cough were divided into the study group and the control group, 100 cases each, by digital parity. Based on the routine treatment, the control group was addnl. treated with ambroxol hydrochloride syrup, and the study group was addnl. treated with Xiao′er Feike granules. After two weeks of treatment, the clin. symptoms and signs in the two groups and the clin. effect were evaluated, and the immune function. Results: The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group, which was statistically significant (P<0.05). Before treatment, the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant (P>0.05). After treatment, the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group (P<0.05). The cough relief time and cough disappearance time in the study group were earlier, what were statistically significant, than those in the control group (P<0.05). There was no significant difference before treatment in the comparison of the levels of CD4+, CD8+, CD4+/CD8+ between all groups (P>0.05). After treatment, the levels of CD8+ in the two groups were increased and the level of the study group was greater than that of the control group;the levels of CD4+ and CD4+/CD8+ were decreased and the level of the study group were greater, which was statistically significant, than those in the control group (P<0.05). Conclusion: Compared with ambroxol hydrochloride syrup, Xiao′er Feike granules is more beneficial to improving the clin. effect, relieving the clin. symptoms and improving the immune resistance of children.

Xin Zhongyi published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C11H10ClNO, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts