Hariri, Ali published the artcileMolecular imaging of oxidative stress using an LED-based photoacoustic imaging system, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Scientific Reports (2019), 9(1), 1-10, database is CAplus and MEDLINE.
LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technol. has largely been confined to anat. imaging with limited applications into functional or mol. imaging. Here, we report mol. imaging reactive oxygen and nitrogen species (RONS) with a near-IR (NIR) absorbing small mol. (CyBA) and LED-based photoacoustic imaging equipment. CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO–) and hydrogen peroxide (H2O2) with photoacoustic signal increases of 3.54 and 4.23-fold at 50μM of RONS at 700 nm, resp. CyBA is insensitive to OCl–, NO, NO2–, NO3–, tBuOOH, O2–, C4H9O , HNO, and OH, but can detect ONOO– in whole blood and plasma. CyBA was then used to detect endogenous RONS in macrophage RAW 246.7 cells as well as a rodent model; these results were confirmed with fluorescence microscopy. Importantly, CyB suffers photobleaching under a Nd:YAG laser but the signal decrease is <2% with the low-power LED-based photoacoustic system and the same radiant exposure time. To the best of our knowledge, this is the first report to describe mol. imaging with an LED-based photoacoustic scanner. This study not only reveals the sensitive photoacoustic detection of RONS but also highlights the utility of LED-based photoacoustic imaging.
Scientific Reports published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.
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