Guo, Chunyang published the artcilePharmaceutical Cocrystals of Nicorandil with Enhanced Chemical Stability and Sustained Release, Synthetic Route of 86-48-6, the publication is Crystal Growth & Design (2020), 20(10), 6995-7005, database is CAplus.
Nicorandil (NCD) is a chem. unstable drug and sensitive to humidity, heat, and mech. stress in manufacturing processes. In this work, the cocrystals of NCD with organic acids were designed and synthesized to enhance the stability of NCD. Cocrystals of NCD with 1-hydroxy-2-naphthoic acid, salicylic acid, 3-hydroxybenzoic acid, and 2,5-dihydroxybenzoic acid were obtained. Hydrothermal stability study showed that cocrystals performed with remarkable stability advantages compared with pure NCD. On the basis of mechanism research, the stability improvements of NCD mols. can be attributed to the realignments of NCD mols. in cocrystals. After the formation of cocrystals, the novel packing styles of NCD break the self-catalyzed decomposition process in pure NCD structure. Moreover, intrinsic dissolution rate characterizations showed that the formation of cocrystals could also optimize the dissolution behavior of NCD to realize the objective of sustained release. The novel cocrystals stabilize nicorandil at mol. levels through lengthening the distances between N1 and C8 of adjacent mols.
Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Synthetic Route of 86-48-6.
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