Jiao, Yang published the artcileA cofactor-substrate-based supramolecular fluorescent probe for the ultrafast detection of nitroreductase under hypoxic Conditions, Quality Control of 622-40-2, the publication is Angewandte Chemie, International Edition (2020), 59(15), 6021-6027, database is CAplus and MEDLINE.
Identifying the location and expression levels of enzymes under hypoxic conditions in cancer cells is vital in early-stage cancer diagnosis and monitoring. By encapsulating a fluorescent substrate, L-NO2, within the NADH mimic-containing metal-organic capsule Zn-MPB, we developed a cofactor-substrate-based supramol. luminescent probe for ultrafast detection of hypoxia-related enzymes in solution in vitro and in vivo. The host-guest structure fuses the coenzyme and substrate into one supramol. probe to avoid control by NADH, switching the catalytic process of nitroreductase from a double-substrate mechanism to a single-substrate one. This probe promotes enzyme efficiency by altering the substrate catalytic process and enhances the electron transfer efficiency through an intra-mol. pathway with increased activity. The enzyme content and fluorescence intensity showed a linear relationship and equilibrium was obtained in seconds, showing potential for early tumor diagnosis, biomimetic catalysis, and prodrug activation.
Angewandte Chemie, International Edition published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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