Ji, Le-ting published the artcileClinical efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(22), 4139-4141, database is CAplus.
Objective: To observe the clin. efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine. Methods: 60 cases of parturients who received carboprost tromethamine injection during cesarean uterine contraction were divided into group A, group B, and group C. Three minutes before intrauterine infusion of carprost tromethamine, group C received i.v. infusion of normal saline, group A received i.v. infusion of penehyclidine hydrochloride 0.5 mg, and group B received i.v. infusion of penehyclidine hydrochloride 1 mg. Result: The incidence of adverse reactions in group A and group B was lower than that in group C, and there was no difference in the incidence of adverse reactions between group A and group B. The levels of motilin and angiotensin in group A and group B were significantly lower than those in group C. Conclusion: Penehyclidine hydrochloride can reduce the clin. adverse reactions of carprost tromethamine. The gastrointestinal adverse reactions may be inhibited by reducing motilin while the cardiovascular adverse reactions may be inhibited by reducing angiotensin II.
Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
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