Cai, Hongfeng published the artcileEffects of dexamethasone combined with ambroxol hydrochloride therapy on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia, Application In Synthesis of 23828-92-4, the publication is Jianyan Yixue Yu Linchuang (2021), 18(8), 1149-1151, database is CAplus.
Objective: To investigate the effect of dexamethasone combined with ambroxol hydrochloride on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia. Methods: A total of 78 patients with severe pneumonia admitted to our hospital from Jan. 2018 to Jan. 2020 were selected and divided into a control group and a research group according to the method of drawing lots, with 39 cases in each group. The control group was treated with a single ambroxol hydrochloride , the study group was treated with dexamethasone on the basis of the control group. The myocardial enzymes [lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK) before and after treatment ) and its isoenzyme (CK-MB)], leukocytes, platelets, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] levels The clin. efficacy and lung function were compared. Results: Before treatment, there was no significant difference in the levels of myocardial enzymes, leukocytes and platelets between the two groups (P>0.05). After treatment, the levels of myocardial enzymes, leukocytes and platelets in the study group were lower than those in the control group (P<0.05). The clin. treatment effect of the patients in the study group was significantly better than that in the control group (P<0.05); there was no significant difference in the pulmonary function between the two groups before treatment (P>0.05), and the pulmonary function of the patients in the study group was better than that in the control group after the treatment (P>0.05). There was no significant difference in the levels of inflammatory factors between the two groups before treatment (P>0.05), and the levels of serum inflammatory factors in the study group were lower than those in the control group after treatment (P<0.05). Conclusion: Dexamethasone combined with ambroxol hydrochloride has a significant effect in the treatment of severe pneumonia, can effectively control the levels of myocardial enzymes, leukocytes and platelets, improve the lung function of patients, and reduce the level of inflammatory factors, which is worthy of clin. application.
Jianyan Yixue Yu Linchuang published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.
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