Nie, Aihua published the artcileDrug discovery based on structure of FKBP52: design and synthesis of 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid derivatives and determination of their activity as neuroimmunophilin ligands, Synthetic Route of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(6), 323-330, database is CAplus.
A method for the synthesis of the title compounds is reported here. One such 2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were investigated for their activity as neuroimmunophilin ligands. SYBYL/Composer was used for homol. modeling the structure of domain 1 (D1) of FKBP52 (a member of the FK506-binding family of immunophilins). Based on the structure of FKBP52D1, CADD (computer-aided drug design) was employed to design and virtually screen such novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives These compounds were synthesized by liquid-phase synthetic method. Cultured chick DRGs (dorsal root ganglion sensory neurons) was applied to evaluate neurotrophic activity of these target compounds Novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were designed based on the structure of FKBP52 and 21 target compounds were synthesized. In cultured chick DRGs, one compound produced potent neurotrophic effects and promoted neurite outgrowth in vitro.
Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.
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