Chen, Sheng published the artcileA high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line, Name: 4,4′-Sulfonyldiphenol, the publication is Chemosphere (2022), 134169, database is CAplus and MEDLINE.
Traditional high-throughput methods for identification of chems. with liver tumor promotion potentials are based on established cancer cell lines, and rapid and cost-effective high-throughput screening assays in whole organisms are presently lacking. In this study, a transgenic zebrafish liver cancer model was employed to develop a method that could be used to identify chems. with liver tumor promotion effect quickly and accurately. The method consisted of three parts, including exposure preparation, exposure process and image acquisition. In brief, after chem. exposure for 7 days, 96-well plate exposure system for zebrafish larvae was assessed by microplate reader. Then, the liver cancer promoting potential chems. were evaluated by field area and field average intensity of fluorescence. The results were further validated by conducting histopathol. examination Our data demonstrated that the high-throughput screening assay developed in this study was reproducible and could be used to rapidly screen chems. with liver tumor promoting potentials by using tris-(2-chloropropyl)-phosphate (TDCIPP) as a pos. control. Furthermore, some other pos. chems. found in previous studies and environmental compounds were assessed using the established method. Results indicated that 86.7% of the pos. chems. and five environmental compounds out of seventeen compounds could enhance liver tumor progression.
Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.
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