Hsin, Ling-Wei published the artcileSynthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor, COA of Formula: C8H19NO, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(8), 707-710, database is CAplus and MEDLINE.
A series of fluoro-substituted 4-(dialkylamino)pyrrolo[2,3-d]pyrimidines was synthesized and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR1) was investigated. Thus, N-ethyl-N-(4-fluorobutyl)-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine and N-(4-fluorobutyl)-2,5,6-trimethyl-N-propyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine possessed very high CRHR1 affinity (Ki=3.5, 0.91 nM, resp.). They are promising candidates for the development of 18F-containing non-peptide PET radioligands for CRHR1.
Bioorganic & Medicinal Chemistry Letters published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, COA of Formula: C8H19NO.
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