Fontenelle, Clement Q. published the artcileDesign of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities, Product Details of C3H5F3O, the publication is Bioorganic & Medicinal Chemistry (2013), 21(23), 7529-7538, database is CAplus and MEDLINE.
Analogs of potent 5-HT4R antagonists possessing a fluorinated N-alkyl chain have been synthesized to investigate the effect of the resulting change in basicity and lipophilicity on the affinity and selectivity profile. The authors demonstrate that for this series, the affinity is decreased with decreased basicity of the piperidine’s nitrogen atom. In contrast, the resulting increase in lipophilicity has minimal impact on binding affinity and selectivity. 3,3,3-Trifluoropropyl and derivatives 7-Fluoro-5-[1-(4,4,4-triuorobutyl)piperidin-4yl]methyloxybenzo[h]-1,6-naphthyridine 4,4,4-trifluorobutyl and 7-Fluoro-5-[1-(3,3,3-triuoropropyl)piperidin-4yl]methyloxybenzo[h]-1,6-naphthyridine have shown to bind to the 5-HT4R while maintaining their pharmacol. profile and selectivity toward other 5-HT receptors.
Bioorganic & Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.
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