Zhang, Yajie published the artcileTargeted Gene Delivery to Macrophages by Biodegradable Star-Shaped Polymers, Quality Control of 96345-79-8, the publication is ACS Applied Materials & Interfaces (2016), 8(6), 3719-3724, database is CAplus and MEDLINE.
In this report, two biodegradable star-shaped polyasparamide derivatives and four analogs modified with either mannose or folic acid moiety for preferential targeting of a difficult-to-transfect immune cell type, i.e., macrophage, have been synthesized. Each of the prepared star polymers complexes with plasmid DNA to form nanosized particles featuring a core-shell-like morphol. Mannose or folate functionalized star polymers can greatly improve the transfection performance on a macrophage cell line RAW 264.7. As a result, a combination of targeting ligand modification and topol. structures of gene carriers is a promising strategy for immune cells-based gene therapy.
ACS Applied Materials & Interfaces published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C8H7ClO3, Quality Control of 96345-79-8.
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