Zhang, Jun published the artcile(E)-β-Trifluoromethyl vinylsulfones as antitumor agents: Synthesis and biological evaluations, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2022), 114197, database is CAplus and MEDLINE.
A three-component reaction of phenylacetylene, trifluoromethyl thianthrenium triflate (TT-CF+3OTf-) and sodium sulfinates under extremely mild conditions is developed, leading to various trifluoromethyl-substituted vinyl sulfones in moderate to good yields with excellent stereoselectivity. Addnl., elaboration of trifluoromethyl-substituted vinyl sulfone by palladium-catalyzed amination is performed. These trifluoromethyl-substituted vinyl sulfones are further evaluated for several assays against different tumor cells and the antitumor mechanism in cytotoxic autophagy induced by PI3K/Akt/mTOR signal is investigated.
European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C9H9NO6S, Category: alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts