Pan, Mingshi published the artcileRuthenium-catalyzed acceptorless dehydrogenative coupling of amino alcohols and ynones to access 3-acylpyrroles, Application In Synthesis of 96-20-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(14), 2379-2382, database is CAplus and MEDLINE.
Herein, a new strategy for the direct synthesis of functionalized pyrroles from β-amino alcs. and ynones via ruthenium-catalyzed acceptorless dehydrogenative coupling was demonstrated. This developed methodol. proceeded in an atom- and step-economic fashion together with the merits of broad substrate scope, operational simplicity, with water and hydrogen gas as the sole byproducts, which provided an alternative and sustainable way to access functionalized pyrroles. Further, this method was applied to the rapid synthesis of the COX-1/COX-2 inhibitor and boron dipyrromethene derivative successfully.
Chemical Communications (Cambridge, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application In Synthesis of 96-20-8.
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