Li, Qihong published the artcileObservation on the effect of dexmedetomidine on reduction of adverse reactions induced by carboprost tromethamine during cesarean section, Product Details of C25H47NO8, the publication is Zhongguo Fuyou Baojian (2015), 30(35), 6368-6370, database is CAplus.
Objective To evaluate the preventive effect of dexmedetomidine on adverse reactions induced by carboprost tromethamine during cesarean section. Methods The pregnant women preparing for low-segment cesarean section were randomly divided into group D (dexmedetomidine), group O (ondansetron), and group C (control group), 30 women in each group. Cesarean section was completed in all the cases under continual epidural anesthesia, then they were treated by i.v. transfusion of 20 U oxytocin after delivery and deltoideus triangularis injection of 250 μg carboprost tromethamine. The cases in group D were treated by i.v. transfusion of dexmedetomidine (load capacity 1 μg/kg, the duration time of i.v. transfusion was less than 10 min, the infusion speed was 0.4 μg·kg-1·h-1) before 10 min of carboprost tromethamine treatment. The cases in group C were treated by i.v. injection of ondansetron after delivery. The cases in group C were treated by normal saline at equal quantity. Mean arterial blood pressure (MAP), heart rate, and SpO2 at 5 min after entering operation room (baseline, T0), 5 min after injection of carboprost tromethamine (T1), and the end of surgery (T2) were recorded. The incidence rates of nausea, vomiting, chest distress, and flushed face from usage of carboprost tromethamine to end of surgery were calculated Modified OAA/S scoring was conducted at T2 and after 2 h of surgery (T3). Results Compared with group D, MAP at T2 and T3 in group C and group O increased significantly, heart rates at T2 and T3 in group C and group O fastened significantly, SpO2 at T2 and T3 in group C and group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, the incidence rates of chest distress, flushed face, nausea, and vomiting in group D decreased significantly, the incidence rates of nausea and vomiting in group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, OAA/S score in group D increased significantly (P<0.05). Conclusion I.v. transfusion of dexmedetomidine before carboprost tromethamine during cesarean section can prevent gastrointestinal and cardiovascular reactions caused by carboprost, the effect is superior to ondansetron.
Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Product Details of C25H47NO8.
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