Wang, Qiong-lin published the artcilePreventive efficacy of carboprost tromethamine on delivery woman having risk factors of postpartum hemorrhage, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(23), 2538-2540, database is CAplus.
The purpose is to investigate clin. efficacy and safety of carboprost tromethamine in prevention of postpartum hemorrhage after high-risk pregnancy cesarean section. 200 Cases of delivery primiparous mothers underwent cesarean section were selected, and randomly divided into observation group and control group, n=100. Patients in the observation group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, then were injected with carboprost tromethamine 250 μg in uterine body, patients in the control group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, meanwhile i.v. injected with oxytocin 10 IU. Operative time, bleeding in operation, postpartum hemorrhage, postpartum hemorrhage incidence, postpartum lochia duration time, postpartum anemia incidence and other conditions of delivery women in two groups were observed There were effective 95 cases and ineffective 5 cases in the observation group, the total effective rate was 95%; there were effective 89 cases and ineffective 13 cases in the control group, the total efficiency was 87%; there was a significant difference in clin. efficacy of two groups (P<0.05). The average operation time and average bleeding amount of the observation group were 37.86 min, and 300.35 mL; the average operation time and average bleeding amount of the control group were 48.19min and 415.66mL; and there were significant differences between two groups (P<0.05). The postpartum hemorrhage amount of delivery woman in the observation group was 368.41 mL, the incidence of postpartum hemorrhage was 5%, the postpartum lochia duration time was (17.32±5.01) d, the incidence of postpartum anemia was 6%; the postpartum hemorrhage amount of delivery woman in the control group was 473.55 mL, the incidence of postpartum hemorrhage was 13%, the postpartum lochia duration time was (23.29±7.91) d, the incidence of postpartum anemia was 15%; and there were significant differences between two groups (P<0.05). Carboprost tromethamine for prevention of postpartum hemorrhage in high-risk pregnancy cesarean section women, is safe and effective, has mild adverse reactions, and is worthy of clin. application.
Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C4H3Cl2NS, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
Referemce:
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