Ma, Stephen J. published the artcileSurface Chemical Functionalization of Wrinkled Thiol-Ene Elastomers for Promoting Cellular Alignment, Quality Control of 7575-23-7, the main research area is cell adhesion polymer; Thiol–ene; cell alignment; cell-matrix interactions; controlled cell culture; mesenchymal stem cells; photopatterning; photopolymerization; substrate wrinkling.
Wrinkled polymer surfaces find broad applicability; however, the polymer substrates are often limited to poly(dimethylsiloxane) (PDMS), which limits spatial control over wrinkle features and surface chem. An approach to surface functionalization of wrinkled elastomer substrates is demonstrated through versatile, multistep thiol-ene click chem. The elastomer is formed using a thiol-Michael reaction of tetrathiol with excess diacrylates while wrinkle formation is induced through a second free radical UV polymerization of the acrylates on the surface of the elastomer. Due to oxygen inhibition of the free radical polymerization, pendant acrylates at the surface remain unreacted and are subsequently functionalized with a multifunctional thiol, which can be further reacted through a number of thiol-X “”click”” reactions. As a demonstration, these thiol surfaces are further modified to either promote cell adhesion of human mesenchymal stem cells (hMSCs) through coupling with RGDS-containing peptides or surface passivation through reaction with hydrophilic hydroxyl Et acrylate moieties. Through engineering both surface chem. and surface topog., hMSCs exhibited increased spreading and cell d. on RGDS-functionalized surfaces and a 2-fold increase in cell alignment when cultured on wrinkled substrates. Gradient-functionalized surfaces created by tuning the wrinkle wavelength with UV irradiation enabled rapid screening of the effect of topog. on the hMSCs. Further, this application of click chem. enables simultaneous tuning of wrinkle topol. and surface chem. toward targeted material applications.
ACS Applied Bio Materials published new progress about Cell adhesion. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.
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