Yu, Peng published the artcileTemperature dependence of mitoflash biogenesis in cardiac mitochondria, Related Products of alcohols-buliding-blocks, the main research area is mitochondrial mitoflash cardiomyocyte temperature.
Mitochondrial flashes represent fundamental biochem. and biophys. dynamics of the organelle, involving sudden depolarization of mitochondrial membrane potential (ΔΨm), bursting production of ROS, and accelerated extrusion of matrix protons. Here we investigated temperature dependence of mitoflash biogenesis as well as ΔΨm oscillations, a subset of which overlapping with mitoflashes, in both cardiac myocytes and cardiac mitochondria. Unexpectedly, we found that mitoflash biogenesis was essentially temperature-independent in intact cardiac myocytes, evidenced by the constancy of frequency as well as amplitude and rise speed over 5°C-40°C. Moderate temperature dependence was found in single mitochondria charged by respiratory substrates, where mitoflash frequency was decreased over 5°C-20°C with Q10 of 0.74 for Complex I substrates and 0.83 for Complex II substrate. In contrast, ΔΨm oscillation frequency displayed a neg. temperature dependence at 5°C-20°C with Q10 of 0.82 in intact cells, but a pos. temperature dependence at 25°C – 40°C with Q10 of 1.62 in isolated mitochondria charged with either Complex I or Complex II substrates. These results suggest a temperature compensation of mitoflash frequency at both the mitochondrial and extra-organelle levels, and underscore that mitoflashes and ΔΨm oscillations are related but distinctly different mitochondrial functional dynamics.
Archives of Biochemistry and Biophysics published new progress about Cardiomyocyte. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.
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