Biswas, Goutam published the artcileNovel guanidine-containing molecular transporters based on lactose scaffolds: lipophilicity effect on the intracellular organellar selectivity, Application In Synthesis of 87905-98-4, the main research area is disaccharide lactose preparation lipophilicity cellular uptake tissue distribution human; blood brain barrier prodrug lipophilicity organelle tissue selectivity guanidine; guanidine mol transporter lactose scaffold lipophilicity intracellular organellar selectivity.
We have synthesized two lactose-based mol. transporters, each containing seven guanidine residues attached to the lactose scaffold through ω-amino-carboxylate linker chains of two different lengths, and have examined their cellular uptake and intracellular and organellar localizations in HeLa cells, as well as their tissue distributions in mice. Both mol. transporters showed higher cellular uptake efficiencies than Arg8, and wide tissue distributions including the brain. Mitochondrial localization is of special interest because of its potential relevance to “”mitochondrial diseases””. Interestingly, it has been found that the intracellular localization sites of the G7 mol. transporters-namely either mitochondria or lysosomes and endocytic vesicles-are largely determined by the linker chain lengths, or their associated lipophilicities.
Chemistry – A European Journal published new progress about Animal tissue. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.
Referemce:
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