Partadiredja, Ginus published the artcileThe Effects of Light and Moderate Intensity Exercise on the Femoral Bone and Cerebellum of -Galactose-Exposed Rats, Category: alcohols-buliding-blocks, the main research area is femoral bone cerebellum exercise galactose; -galactose; exercise; growth factor; osteoblast; osteoclast.
The present study aimed at investigating the effects of exercise on cerebellar and serum growth factors, motor activity, and the number of bone cells of the femoral head of -galactose-treated rats. Twenty-four male Wistar rats were divided randomly into four groups, i.e., three treated groups injected with 300 mg/(mL·kg) body weight (bw) -galactose solution daily for 4 wk, and a control group injected with normal saline. Following the 4-wk administration of -galactose solution, two of the treated groups performed light- (45% VO2max) and moderate- (55% VO2max) intensity exercise, by running on a treadmill 4 × a week for 4 wk. Locomotor activity was examined in rotarod and open field tests. The cerebellar and serum Insulin-like Growth Factor 1 (IGF-1) and Brain-Derived Neurotrophic Factor (BDNF) levels were measured using ELISA (ELISA). The number of osteoblasts and osteoclasts of femoral head was estimated using unbiased stereol. methods. It was found that the number of osteoclasts was higher in the -galactose-treated group than the normal control and moderate-intensity exercise groups. No significant difference between groups was found in the rotarod and open field test performance, IGF-1 and BDNF levels, as well as number of osteoblasts. In conclusion, a 4-wk administration of high-dose-galactose caused the increase of the number of osteoclasts. A subsequent 4-wk moderate-intensity exercise reversed this increase to the normal level.
Rejuvenation Research published new progress about Aging, animal. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.
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