Huber, Matthias C. published the artcileMinimalist Protocell Design: A Molecular System Based Solely on Proteins that Form Dynamic Vesicular Membranes Embedding Enzymatic Functions, Application In Synthesis of 111-87-5, the main research area is dynamic vesicular membrane amphiphilic elastin like protein; artificial cells; biocatalysis; enzyme catalysis; protocells; synthetic biology.
Life in its mol. context is characterized by the challenge of orchestrating structure, energy and information processes through compartmentalization and chem. transformations amenable to mimicry of protocell models. Here we present an alternative protocell model incorporating dynamic membranes based on amphiphilic elastin-like proteins (ELPs) rather than phospholipids. For the first time we demonstrate the feasibility of combining vesicular membrane formation and biocatalytic activity with mol. entities of a single class: proteins. The presented self-assembled protein-membrane-based compartments (PMBCs) accommodate either an anabolic reaction, based on free DNA ligase as an example of information transformation processes, or a catabolic process. We present a catabolic process based on a single mol. entity combining an amphiphilic protein with tobacco etch virus (TEV) protease as part of the enclosure of a reaction space and facilitating selective catalytic transformations. Combining compartmentalization and biocatalytic activity by utilizing an amphiphilic mol. building block with and without enzyme functionalization enables new strategies in bottom-up synthetic biol., regenerative medicine, pharmaceutical science and biotechnol.
ChemBioChem published new progress about Amphipathicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.
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