Pilkington, Lisa I. published the artcileA chemometric analysis of deep-sea natural products, Safety of n-Octanol, the main research area is cytarabine vidarabine trabectedin pharmacokinetics natural product; chemical space; deep-sea; drug-like; known drug space; lead-like; natural products.
In this study, 179 deep-sea natural products isolated from 2009 to 2013 were investigated by analyzing their physicochem. properties that are important indicators of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) profile of a compound The study and anal. of these mol. descriptors and characteristics enabled the defining of these compounds in various chem. spaces, particularly as an indication of their drug-likeness and position in chem. space and is the first to be conducted to analyze deep-sea derived natural products. It was found that ~40% of all deep-sea natural products were drug-like and 2/3 were within Known Drug Space (KDS), highlighting the high drug-likeness of a significant proportion of deep-sea natural products, most of which have already been shown to have notable biol. activities, that should be further investigated as potential therapeutics. Furthermore, this study was able to reveal the general structural differences between compounds from Animalia, Bacteria and Fungi organisms where it was observed that natural products from members of the Animalia kingdom are structurally more varied than compounds from bacteria and fungi. It was also noted that, in general, fungi-derived compounds occupy a more favorable position in drug-like chem. space and are a rich and promising source of biol.-active natural products for the purposes of drug development and therapeutic application.
Molecules published new progress about Actinobacteria. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts