Jang, Eun Ha published the artcileInvestigation of the effects of materials and dry granulation process on the mirabegron tablet by integrated QbD approach with multivariate analysis, COA of Formula: C12H24O11, the main research area is dry granulation mirabegron tablet QbD.
The purpose of this study was to evaluate the relationship among numerous variables to enhance the understanding of the effects of materials and process parameters on drug product quality. The study consisted of two stages: the first stage involved exptl. designing to optimize formulation and process parameters, and the second stage involved assessing the relationship between intermediate quality attributes (IQAs) and critical quality attributes (CQAs) by multivariate anal. (MVA). Initial risk assessment was conducted to select critical material attributes (CMAs) and critical process parameters (CPPs), which have a high effect on CQAs and IQAs. The correlation between IQAs and CQAs was confirmed via Pearson correlation anal. and principal component anal. The robustness of the correlation was verified using a wide range of variables. Therefore, the study suggests that risk in the development of drug products can be reduced via an integrated quality by design (QbD) approach employing MVA.
Powder Technology published new progress about Dry granulation. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts