Yan, Jingmin published the artcileA 3-O-methylated heterogalactan from Pleurotus eryngii activates macrophages, Product Details of C6H12O6, the main research area is Pleurotus heterogalactan macrophage MAPK NFkappaB TLR2 signaling; Heterogalactan; MAPKs; Macrophage; NF-κB; Pleurotus eryngii; TLR2.
Mushroom-derived polysaccharides exhibit various biol. activities owing to their diverse structural features. Here, we purified a 3-O-methylated heterogalactan (WPEP-N-b, Mw 21.4 kDa) from the fruiting bodies of Pleurotus eryngii. WPEP-N-b is composed primarily of galactose (43.8%), mannose (39.3%), methyl-galactose (11.7%) and glucose (9.2%) residues, with the main chain being composed of α-1,6-linked D-Galp and 3-O-Me-D-Galp, branched at O-2 with single t-β-D-Manp as major the side chain. β-1,6-D-Glcp residues are present as minor components either in side-chains or backbone. WPEP-N-b increases macrophage phagocytosis and secretion of NO, TNF-α, IL-6 and IL-1β. Mechanistic studies demonstrate that WPEP-N-b promotes the degradation of IκB-α, and enhances phosphorylation of MAPKs and the NF-κB p65 subunit. Our results also indicate that this polysaccharide activates RAW264.7 cells via MAPK and NF-κB signaling pathways and the Toll-like receptor 2(TLR2). These results increase our understanding as to how mushroom-derived polysaccharides modulate the immunol. process.
Carbohydrate Polymers published new progress about Cell activation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.
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