Ndindayino, F. published the artcileBioavailability of hydrochlorothiazide from isomalt-based moulded tablets, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is hydrochlorothiazide isomalt molded tablet bioavailability.
The bioavailability of hydrochlorothiazide (HCT) from molded isomalt-based tablets was evaluated after oral administration of 50 mg HCT to healthy volunteers as an oral molded tablet and as a lozenge, in comparison with a conventional tablet formulation (Dichlotride® 50 mg). Molded tablets had a high relative bioavailability (Frel) as the pharmacokinetic parameters (Cmax, tmax, t1/2, AUC0 24 h) determined from HCT plasma concentration vs. time profiles were not significantly different (P>0.05; two-way ANOVA) in comparison with the conventional tablet. The relative bioavailability of the molded tablet administered as a lozenge and as an oral tablet was 106.2±30.9% and 89.4±25.9%, resp., in relation to the conventional tablet formulation. Direct molding of isomalt tablets proved to be a suitable technique to administer a poorly soluble drug either as a conventional tablet or as a lozenge.
International Journal of Pharmaceutics published new progress about Bioavailability. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts