Alkhalidi, Bashar A. published the artcileClarithromycin laurate salt: physicochemical properties and pharmacokinetics after oral administration in humans, Category: alcohols-buliding-blocks, the main research area is clarithromycin laurate salt tablet oral drug delivery pharmacokinetics; Clarithromycin laurate; bioavailability; fatty acid salt; physicochemical characterization.
To prepare and characterize the physicochem. and pharmacokinetic properties of clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM). CLM-L was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR, 1H NMR, and 13C NMR. Solubility, intrinsic dissolution rate (IDR), and partitioning properties of CLM-L were determined and compared to those of CLM. Bioavailability of CLM from CLM-L tablets was evaluated in healthy volunteers and compared to immediate release CLM tablets. CLM-L showed lower aqueous solubility, higher partitioning coefficient, and slower dissolution rate. Tablets of CLM-L also showed a significantly slower in vitro release in comparison to CLM tablets. Cmax, Tmax and AUC0→inf of CLM-L tablets and immediate release CLM tablets did not show a significant difference. However, the AUC0→inf for the CLM-L tablets tended to be higher than that of CLM tablets at all-time points. CLM-L was successfully prepared and its formation was confirmed. CLM-L was more hydrophobic than CLM. It exhibited a slight in vivo absorption enhancement in comparison to CLM. However, its pharmacokinetic behavior was comparable to that of CLM.
Pharmaceutical Development and Technology published new progress about Bioavailability. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts