Michnova, Hana published the artcileBioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: comparative molecular surface analysis, Product Details of C11H8O3, the publication is Molecules (2019), 24(16), 2991, database is CAplus and MEDLINE.
A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-carboxanilides was prepared and characterized as potential anti-invasive agents. The mol. structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analyzed compounds were tested against the reference strain Staphylococcus aureus and three clin. isolates of methicillin-resistant S. aureus as well as against Mycobacterium tuberculosis and M. kansasii. In addition, the inhibitory profile of photosynthetic electron transport in spinach (Spinacia oleracea L.) chloroplasts was specified. In vitro cytotoxicity of the most effective compounds was tested on the human monocytic leukemia THP-1 cell line. The activities of N-(3,5-dimethylphenyl)-, N-(3-fluoro-5-methoxy-phenyl)- and N-(3,5-dimethoxyphenyl)-1-hydroxynaphthalene-2-carbox-amide were comparable with or even better than the commonly used standards ampicillin and isoniazid. All promising compounds did not show any cytotoxic effect at the concentration >30 μM. Moreover, an in silico evaluation of clogP features was performed for the entire set of the carboxamides using a range of software lipophilicity predictors, and cross-comparison with the exptl. determined lipophilicity (log k), in consensus lipophilicity estimation, was conducted as well. Principal component anal. was employed to illustrate noticeable variations with respect to the mol. lipophilicity (theor./exptl.) and rule-of-five violations. Addnl., ligand-oriented studies for the assessment of the three-dimensional quant. structure-activity relationship profile were carried out with the comparative mol. surface anal. to determine electron and/or steric factors that potentially contribute to the biol. activities of the investigated compounds
Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.
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