Lowenthal, Mark S.’s team published research in Analytical and Bioanalytical Chemistry in 405 | CAS: 526-98-7

Analytical and Bioanalytical Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Lowenthal, Mark S. published the artcileDeveloping qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials, HPLC of Formula: 526-98-7, the publication is Analytical and Bioanalytical Chemistry (2013), 405(13), 4451-4465, database is CAplus and MEDLINE.

Standard Reference Materials (SRMs) offer the scientific community a stable and homogeneous source of material that holds countless application possibilities. Traditionally, the National Institute of Standards and Technol. (NIST) has provided SRMs with associated quant. information (certified values) for a select group of targeted analytes as measured in a solution or complex matrix. While the current needs of the SRM community are expanding to include non-quant. data, NIST is attempting to broaden the scope of how and what information is offered to the SRM community by providing qual. information about biomaterials, such as chromatog. fingerprints and profiles of untargeted identifications. In this work, metabolomic and proteomic profiling efforts were employed to characterize a suite of six Vaccinium berry SRMs. In the discovery phase, liquid chromatog.-tandem mass spectrometry (LC-MS/MS) data was matched to mass spectral libraries; a subsequent validation phase based on multiple-reaction monitoring LC-MS/MS relied on both retention time matching of authentic standards along with fragmentation data for a qual. overview of the most prominent organic compounds present. Definitive and putative identifications were determined for over 70 metabolites based on reporting guidelines set forth by the Metabolomics Standards Initiative (Metabolomics 3(3):211-221, 2007), and the capability of electrospray ionization mass spectrometry (ESI-MS) to profile untargeted metabolites within a complex matrix using mass spectral matching is demonstrated. Bottom-up proteomic analyses were possible using peptide databases translated from expressed sequence tags (ESTs). Homol. searches provided identification of novel Vaccinium proteins based on homol. to related genera. Chromatog. fingerprints of these berry materials were acquired for supplemental qual. information to be provided to users of these SRMs. An unbounded set of qual. data about a biomaterial is a valuable complement to quant. information traditionally provided in NIST Certificates of Anal.

Analytical and Bioanalytical Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

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