Nischang, Ivo published the artcileHydrodynamic Analysis Resolves the Pharmaceutically-Relevant Absolute Molar Mass and Solution Properties of Synthetic Poly(ethylene glycol)s Created by Varying Initiation Sites, Product Details of C12H20O6, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(2), 1185-1193, database is CAplus and MEDLINE.
The solution behavior originating from mol. characteristics of synthetic macromols. plays a pivotal role in many areas, in particular the life sciences. This situation necessitates the use of complementary hydrodynamic anal. methods as the only means for a complete structural understanding of any macromol. in solution To this end, we present a combined hydrodynamic approach for studying inhouse prepared, low dispersity poly(ethylene glycols)s (PEGs), also known as poly (ethylene oxide)s (PEOs) depending on the classification used, synthesized from varying initiation sites by living anionic ring opening polymerization The series of linear PEGs in the molar mass range of only a few thousand to 50 000 g mol-1 were studied in detail via viscometry, and sedimentation-diffusion anal. by anal. ultracentrifugation. The obtained estimations for intrinsic viscosity, diffusion coefficients, and sedimentation coefficients of the macromols. in the solution-based anal. clearly showed self-consistency of the followed hydrodynamic approach. This self-consistency is underpinned by appropriate and phys.-sound values of hydrodynamic invariants, indicating adequate values of derived absolute molar masses. The classical scaling relations of Kuhn-Mark-Houwink-Sakurada of all molar-mass dependent hydrodynamic estimates show linear trends, allowing for interrelation of all parametric macromol. characteristics. Differences among these are ascribed to the observation of α-end and chain-length dependent solvation of the macromols., identified from viscometric studies. This important information al-lows for anal. tracing of variations of scaling relationships and a phys.-sound estimation of hydrodynamic characteristics. The demonstrated self-sufficient methodol. paves an important way for a complete structural understanding and potential replacement of pharmaceutically-relevant PEGs by alternative macromols. offering a suite of similar or tractably distinct physicochem. properties.
Analytical Chemistry (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.
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