Straker, R. N. published the artcileComputational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Nature Communications (2016), 10109, database is CAplus and MEDLINE.
Many diastereoselective (substrate stereocontrol), and enantioselective (catalyst stereocontrol) cycloisomerizations was developed. However, asym. cycloisomerizations where a chiral catalyst specifies the stereochem. outcome of the cyclization of a single enantiomer substrate-regardless of its inherent preference-were unknown. A combined theor. and exptl. approach enables the design of a highly reactive rhodium catalyst for the stereoselective cycloisomerization of ynamide-vinylcyclopropanes to [5.3.0]-azabicycles was showed. Highly diastereoselective cycloisomerizations using an achiral catalyst, and then explored phosphoramidite-complexed rhodium catalysts in the enantioselective variant, where theor. investigations uncovered an unexpected reaction pathway in which the electronic structure of the phosphoramidite dramatically influences reaction rate and enantioselectivity was established. A marked enhancement of both was observed using the optimal theory-designed ligand, which enabled double stereodifferentiating cycloisomerizations in both matched and mismatched catalyst-substrate settings.
Nature Communications published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C20H22ClN3O3, Recommanded Product: (R)-Oxiran-2-ylmethanol.
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