Galman, James L. published the artcileOne-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(8), e202112855, database is CAplus and MEDLINE.
Electron-rich phenolic substrates can be derived from the depolymerization of lignin feedstocks. Direct biotransformations of the hydroxycinnamic acid monomers obtained can be exploited to produce high-value chems., such as α-amino acids, however the reaction is often hampered by the chem. autoxidation in alk. or harsh reaction media. Regioselective O-methyltransferases (OMTs) are ubiquitous enzymes in natural secondary metabolic pathways utilizing an expensive co-substrate S-adenosyl-L-methionine (SAM) as the methylating reagent altering the physicochem. properties of the hydroxycinnamic acids. In this study, we engineered an OMT to accept a variety of electron-rich phenolic substrates, modified a com. E. coli strain BL21 (DE3) to regenerate SAM in vivo, and combined it with an engineered ammonia lyase to partake in a one-pot, two whole cell enzyme cascade to produce the L-DOPA precursor L-veratrylglycine from lignin-derived ferulic acid.
Angewandte Chemie, International Edition published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.
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