Yang, Ling published the artcileThe pH-influenced PET processes between pyronine and different heterocycles, Related Products of alcohols-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2017), 15(39), 8402-8409, database is CAplus and MEDLINE.
The OFF-ON and ON-OFF type pH probes based on rosamine were designed by using the relative electron densities between pyronine and various linked heterocycles. Probe 1a with an indole-pyronine skeleton gave an OFF-ON pH response (pKa = 1.41) with decreasing pH, and the relative fluorescence intensity increased 15-fold, while probe 1b with an imidazole-pyronine skeleton did not give an ON-OFF response to different pH values. When pyronine was connected with a quinolinyl group, i.e., probes 1c-d, the red emission (around 575-800 nm) gave a monotonous ON-OFF pH response (pKa = 3.26 and 2.62, resp.) with decreasing pH. The relative fluorescence intensities decreased 263- and 46-fold, resp. Changes in the electron donating abilities of the nitrogen containing heterocycles were used to explain variations in PET processes within the probes, and their pH-dependent PET mechanisms were verified using time-dependent d. functional theory calculations Confocal fluorescence imaging was also used to evaluate the potential biomedical application of probes 1a-d. Ultimately, probe 1d (I) with an appropriate pKa value and good biocompatibility showed lysosome targeting ability.
Organic & Biomolecular Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C11H21BF4N2O2, Related Products of alcohols-buliding-blocks.
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