Haga, Yuji published the artcileDiscovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Bioorganic & Medicinal Chemistry (2011), 19(2), 883-893, database is CAplus and MEDLINE.
The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c (I), exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.
Bioorganic & Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.
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