Skorenski, Marcin published the artcilePhosphonate inhibitors of West Nile virus NS2B/NS3 protease, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 8-14, database is CAplus and MEDLINE.
West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)P(OPh)2 displaying Ki and k2/Ki values of 0.4 μM and 28 265 M-1s-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14O3, Application of 4,4-Diethoxybutan-1-amine.
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