Glycoconjugate Journal published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, SDS of cas: 96345-79-8.
Derrien, Daniele published the artcileMuramyl dipeptide bound to poly-L-lysine substituted with mannose and gluconoyl residues as macrophage activators, SDS of cas: 96345-79-8, the publication is Glycoconjugate Journal (1989), 6(2), 241-55, database is CAplus and MEDLINE.
Poly(L-lysine) modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP). The effect of the acylating agent on the targeting efficiency was investigated: a hydrosolubilizing group such as a gluconoyl moiety led to very efficient carrier conjugates, while an acetyl group did not. The effect of sugar and acyl content of the polymers was assessed using these compounds as inhibitors of red blood cell agglutination by Con A. The binding and specific endocytosis of poly(L-lysine) substituted with several mannose derivatives and gluconoyl residues (GlcAx-, Many-PLK) were determined by a quant. flow cytometry anal. MDP bound to these conjugates was much more efficient in vitro than free MDP in macrophage cytostasis assays.
Glycoconjugate Journal published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, SDS of cas: 96345-79-8.
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