Tran, Chieu D. published the artcileChiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis, Category: alcohols-buliding-blocks, the publication is Journal of Chromatography A (2008), 1204(2), 204-209, database is CAplus and MEDLINE.
A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA]+[Tf2N]–), which can be easily and readily synthesized in a one-step process from com. available reagents, can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, warfarin, indoprofen, ketoprofen, ibuprofen and flurbiprofen, can be successfully and baseline separated with the use of this IL as electrolyte. Interestingly, while S-[CHTA]+[Tf2N]– can also serve as a chiral selector, enantioseparation cannot be successfully achieved with S-[CHTA]+[Tf2N]– as the only chiral selector. In the case of ibuprofen, a second chiral selector, namely a chiral anion (sodium cholate), is needed for the chiral separation For flurbiprofen, in addition to S-[CHTA]+[Tf2N]– and sodium cholate, a third and neutral chiral selector, 1-S-octyl-β–thioglucopyranoside (OTG), is also needed. Due to the fact that the chirality of this chiral IL resides on the cation (i.e., -[CHTA]+), and that needed addnl. chiral selector(s) are either chiral anion (i.e., cholate) or chiral neutral compound (OTG), the results obtained seem to suggest that addnl. chiral selector(s) are needed to provide the three-point interactions needed for chiral separations
Journal of Chromatography A published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C3H5BN2O2, Category: alcohols-buliding-blocks.
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