Nakanishi, Masako published the artcileDietary walnut supplementation alters mucosal metabolite profiles during DSS-induced colonic ulceration, Application of Triisopropanolamine, the publication is Nutrients (2019), 11(5), 1118, database is CAplus and MEDLINE.
Walnuts contain a complex array of natural compounds and phytochems. that exhibit a wide range of health benefits, including protection against inflammation and colon cancer. In this study, we assess effect of dietary supplementation with walnuts on colonic mucosal injury induced in mice by ulcerogenic agent, dextran sodium sulfate (DSS). C57Bl/6J mice were started on the Total Western Diet supplemented with freshly-ground whole walnuts (0, 3.5, 7 and 14% g/kg) 2 wk prior to a 5-day DSS treatment and walnut diets were continued throughout the entire exptl. period. In a sep. study, a discovery-based metabolite profiling anal. using liquid chromatog. tandem mass spectrometry was performed on fecal samples and colonic mucosa following two weeks of walnut supplementation. Dietary walnut supplementation showed significant effects in the 10-day post-DSS recovery-phase study, in which the extent of ulceration was significantly reduced (7.5% vs. 0.3%, p < 0.05) with 14% walnuts. In the metabolite-profiling anal., walnuts caused a significant increase in several polyunsaturated fatty acids, including docosahexaenoic acid and 9-oxo-10(E),12(E)-octadecadienoic acid (9-oxoODA), as well as kynurenic acid. In colon tissue samples, walnuts caused a significant increase in the levels of S-adenosylhomocysteine and betaine, important components of fatty acid β-oxidation These metabolite changes may contribute in part to the observed protection against DSS-induced inflammatory tissue injury.
Nutrients published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.
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