Dave, H. N. published the artcileApplication of two advanced derivative spectrophotometric methods for simultaneous estimation of salbutamol sulphate, ambroxol hydrochloride and theophylline in pure and commercial formulations, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is International Journal of Current Pharmaceutical Research (2022), 14(3), 33-38, database is CAplus.
Two advanced spectrophotometric methods have been proposed for the simultaneous determination of Salbutamol sulfate, Ambroxol hydrochloride and Theophylline in pure and pharmaceutical formulations. The proposed methods exclude the hectic steps of time-consuming sample preparations or purification or separation steps. There is no any spectrophotometric method has been avail for simultaneous estimation of the ternary mixture containing Salbutamol sulfate, Ambroxol hydrochloride and Theophylline. The methods are derivative ratio spectra zero-crossing method and double divisor ratio spectra derivative method resp. Both the methods are found to be rapid, accurate, precise, reliable and economical as well. The developed methods show best results in terms of linearity, accuracy, precision, limit of detection and limit of quantification for standard laboratory mixtures of pure drugs and marketed formulations. The range for Salbutamol sulfate, Ambroxol hydrochloride and Theophyllineare found to be 1-35μg ml-1, 5-35μg ml-1 and 6-60μg ml-1 resp. For the derivative ratio spectra zero-crossing method, the values of the limit of detection are found to be 0.3161μg ml-1, 0.2212μg ml-1 and 0.2910μg ml-1 and the values limit of quantification are found to be 0.9571μg ml-1, 0.7412μg ml-1 and 0.9671μg ml-1 for Salbutamol sulfate, Ambroxol hydrochloride and Theophylline resp. For double divisor ratio spectra derivative method, limit of detection values is found to be 0.3251μg ml-1, 0.2591μg ml-1 and 0.2640μg ml-1 and the limit of quantification values are found to be 0.9870μg ml-1, 0.8650μg ml-1 and 0.8812μg ml-1 for Salbutamol sulfate, Ambroxol hydrochloride and Theophylline resp. The common excipients and additives did not interfere in the determinations of any of the drugs while being analyzed for com. formulations. These two spectrophotometric methods, which determine SS, AH, and THE simultaneously, are simple, specific, accurate, precise, rapidly, and economically, indicating that they can be used routinely in pharmaceutical anal. As a result, derivative spectrophotometry may be used effectively for the simultaneous determination of SS, AH and THE in the combined dosage forms without any prior separation of individual drugs.
International Journal of Current Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.
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