Tsarev, Vasily N. published the artcileP-chiral monodentate diamidophosphites – New and efficient ligands for palladium-catalysed asymmetric allylic substitution, Recommanded Product: 1-Methylcyclobutan-1-ol, the publication is European Journal of Organic Chemistry (2004), 2214-2222, database is CAplus.
Monodentate hexahydropyrrolodiazaphosphole ligands I [R = MeO, Me2CHO, Me3CO, (F3C)2CHO, 1-Me-1-cyclobutoxy, 1-adamantyloxy, (-)-menthyloxy, PhO, Et2N, 1-piperidinyl] are prepared and used as ligands for enantioselective allylic substitution and amination reactions of 1,3-diphenylallyl acetate with sodium 4-methylbenzenesulfinate, benzylamine, and di-Me malonate to give substitution products in up to 97% ee. Reaction of alcs. or amines with I (R = Cl) [prepared in one step from (2R)-2-(phenylaminomethyl)pyrrolidine and PCl3] yields I [R = MeO, Me2CHO, Me3CO, (F3C)2CHO, 1-Me-1-cyclobutoxy, 1-adamantyloxy, (-)-menthyloxy, PhO, Et2N, 1-piperidinyl]. I are isolated as mixtures of epimers at phosphorus favoring the (RP)-configuration. Dinaphthodioxaphosphepines derived from (R)-BINOL are also prepared as nonracemic ligands for comparison. Dimeric rhodium complexes and a monomeric rhodium complexes are prepared from I and [Rh(CO)2Cl]2 and characterized by 31P NMR. (allyl)palladium complexes derived from I and allylpalladium chloride dimer are prepared as catalysts for allylic substitution and amination reactions; the complexes can also be generated in situ using either allylpalladium chloride dimer or tris(dibenzylideneacetone)dipalladium as precursors, but in some cases the use of in situ generated catalysts gives products with decreased enantioselectivities. The most effective catalysts are those containing phosphine ligands with moderate π-acidity; less π-acidic ligands give decreased enantioselectivities. The enantioselectivity of allylic amination reactions using I and their derived palladium complexes increases as the cone angle of the phosphine increases. Allylic alkylation of (allyl)(methyl)carbonate with a carborane-containing phenylacetic acid ester gives an (allyl)(carboranyl)phenylacetate ester in up to 73% ee, the first direct asym. reaction for a carborane derivative
European Journal of Organic Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C2H2N4O2, Recommanded Product: 1-Methylcyclobutan-1-ol.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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