Caliskan, Burcu published the artcilePyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is European Journal of Medicinal Chemistry (2011), 46(10), 5021-5033, database is CAplus and MEDLINE.
Thirty-six title compounds were synthesized and led to potent inhibition of leukotriene (LT) biosynthesis in activated human neutrophils. Some examples showed IC50 values in the range of 1.6-3.5 μM. Moreover, several compounds showed a substantial inhibition of platelet COX-1 activity with IC50 of 2.5, 0.041, 0.3, 0.9 and 0.014 μM, resp., leading up to dual acting inhibitors. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-propanoic acid derivatives may possess potential in the design of more potent compounds for intervention with inflammatory and allergic diseases.
European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.
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