Yong, Jian-Ping published the artcilePotential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(1), 131-136, database is CAplus and MEDLINE.
14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.
Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.
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