Zhang, Yongjie published the artcilePyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation, HPLC of Formula: 96-20-8, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127712, database is CAplus and MEDLINE.
Tropomyosin receptor kinases (Trks), a transmembrane receptor tyrosine kinases, have attracted more and more attention as antitumor drug targets. Here we reported the structure-based synthesis and biol. evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives, i.e., I, as Trk inhibitors, which exhibited potent Trk inhibitory activities. Particularly, some of the compounds (8a, 8f, 9a, 9b and 9f) (IC50 < 5 nM) showed significant inhibitory potency against Trk.
Bioorganic & Medicinal Chemistry Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H6ClF3, HPLC of Formula: 96-20-8.
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