Zhang, Zhenguo published the artcileMetal-Free Access to (Spirocyclic)Tetrahydro-β-carbolines in Water Using an Ion-Pair as a Superacidic Precatalyst, COA of Formula: C10H18O, the publication is ACS Catalysis (2022), 12(3), 2052-2057, database is CAplus.
The unprecedented triarylcarbonium ion-pair-catalyzed Pictet-Spengler reaction of tryptamines with aromatic aldehydes and cyclic ketones in water was disclosed. Under metal-free conditions, diverse tetrahydro-β-carbolines/spirocyclic tetrahydro-β-carbolines I [R1 = H, Me, Cl, etc.; R2 = H; R3 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2R3 = (CH2)5, CH2CH2CH(Me)CH2CH2, CH2CH2N(Boc)CH2CH2, etc.] were obtained in good yields with excellent functional group tolerance, including late-stage modification of natural products and small mol. drugs. The practicability of this protocol was also characterized in the gram-scale synthesis of komavine and several other functional compounds Preliminary mechanistic studies indicated that in aqueous media the in situ-generated superacidic species from the carbonium ion pair with water was crucial to promote the Pictet-Spengler reaction.
ACS Catalysis published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C12H10O4S, COA of Formula: C10H18O.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts