Wu, Huaimo published the artcileAn efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions, Name: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Organic & Biomolecular Chemistry (2021), 19(18), 4126-4131, database is CAplus and MEDLINE.
In this report, a mild, efficient and green method for the synthesis of 1,2-dihydroxanthones (DHXs) I (R = H, Me, 3-methylbut-2-en-1-yl; R1 = H, Me; R2 = Me, Ph, 2,2,2-trifluoroethyl, but-3-en-1-yl, etc.; R3 = H, Me; R4 = H, F, OMe, Cl, Br, I; R5 = H, Me, OMe, Cl, CF3, F; R4R5 = -CH:CHCH:CH-; R6 = H, Cl, Me, prop-2-en-1-yl) and II (R7 = H, OMe) has been developed in one pot through Claisen condensation and O-cyclization under waste-induced relay catalysis with min. organic solvents. The byproduct (HMDS or NH3·H2O) of the first step turned out to be the promoter for the second step, which could efficiently proceed in aqueous media without the addition of other catalysts. The reactions using trifluoroethyl salicylates 2-OH-3-R6-4-R5-5-R4-6-R3C6HC(O)OCH2CF3 could be performed under mild conditions to ensure the generation of vulnerable DHXs I and II in high yields. The substrate scope is very broad regardless of the substituent type and its position on the structure. Specifically, the versatility of DHXs I (R = R1 = R3 = R4 = R5 = R6 = H; R2 = Me) was demonstrated by their conversion to xanthones I (R = 3-methylbut-2-en-1-yl; R1 = R3 = R4 = R5 = R6 = H; R2 = Me)/II (R7 = H) and other complex structures III/IV.
Organic & Biomolecular Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C18H28BNO2, Name: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.
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