Tsai, Charng-Sheng published the artcileDevelopment of trifunctional probes for glycoproteomic analysis, Safety of 3-(Methylamino)phenol, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(30), 5575-5577, database is CAplus and MEDLINE.
Here the authors examine the applications of two trifunctional probes with different linkers for their abilities in both target detection via 3-azido-7-aminocoumarin and enrichment via biotin, when reacting with alkynyl sugars. Probe I carries an azido group for both conjugation and fluorescent triggering. When the 1,2,3-triazole ring was formed by Cu(I)-catalyzed Azide-Alkyne (3 +2) Cycloaddition, it activated the fluorescent property of 3-azido-7-aminocoumarin to provide a high fluorescent signal for rapid and sensitive target detection, while the biotin group in probe I offered the advantage of glycoprotein enrichment. To increase the elution yield of labeled targets that bind to streptavidin matrixes, the authors further introduced a cleavable linker (cystamine) between 3-azido-7-aminocoumarin and biotin in probe II. Thus after binding to streptavidin matrixes, the labeled targets can be recovered by treatment with reducing agents such as dithiothreitol or tris(2-carboxyethyl)phosphine to break the disulfide bond and give fluorescent labeled biomols.
Chemical Communications (Cambridge, United Kingdom) published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C6H12O2, Safety of 3-(Methylamino)phenol.
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